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ONE OF TIME'S
BEST INVENTIONS

Learn more about the option to switch to
LEQEMBI IQLIK after 18 months of infusions.

One of TIME'S BEST INVENTIONS 2025. From TIME © 2025 TIME USA LLC.
All Rights Reserved. Used under license.

leh kem' bee LEQEMBI

leh kan' uh mab lecanemab

LEQEMBI i-click LEQEMBI IQLIK

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Medication Guide
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- Prescribing Information (English)
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- 360 mg Autoinjector — Instructions for Use (English)
- 360 mg Autoinjector — Instructions for Use (Spanish)

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Early
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IMPORTANT SAFETY INFORMATION

WHAT IS LEQEMBI?

LEQEMBI is a prescription medicine used to treat people with early Alzheimer’s disease, which includes mild cognitive impairment (MCI) or mild dementia stage of disease.

EXPAND COLLAPSE

WHAT IS LEQEMBI?

LEQEMBI is a prescription medicine used to treat people with early Alzheimer’s disease, which includes mild cognitive impairment (MCI) or mild dementia stage of disease.

WHAT IS LEQEMBI?

LEQEMBI is a prescription medicine used to treat people with early Alzheimer’s disease, which includes mild cognitive impairment (MCI) or mild dementia stage of disease.

IMPORTANT SAFETY
INFORMATION

What is the most important information I should know about LEQEMBI?

LEQEMBI can cause serious side effects, including:

ARIA (Amyloid-Related Imaging Abnormalities). ARIA is a side effect that does not usually cause any symptoms, but serious symptoms can occur. ARIA can be fatal.

ARIA commonly shows up as temporary swelling in areas of the brain that usually goes away over time
Small spots of bleeding in or on the surface of the brain can occur
Less often, larger areas of bleeding in the brain can occur
Most people with ARIA don’t have any symptoms. However, some people may notice:

– headache

– confusion that gets worse

– dizziness

– vision changes

– nausea

– difficulty walking

– seizures

– difficulty speaking

– muscle weakness

Some people have a gene called ApoE4 that may increase the risk of ARIA. Talk to your healthcare provider about testing to see if you have this gene
You may be at a higher risk of developing bleeding in the brain if you take medicines to reduce blood clots from forming (antithrombotic medicines) while receiving LEQEMBI. Talk to your healthcare provider to see if any of the medicines you’re taking increase this risk
Your healthcare provider will check for ARIA with MRI (magnetic resonance imaging) scans before you start LEQEMBI and during treatment
You should carry information that says you are receiving LEQEMBI, which can cause ARIA, and that ARIA symptoms can look like stroke symptoms

Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the symptoms listed above.

Serious allergic reactions:

Do not receive LEQEMBI if you have serious allergic reactions to LEQEMBI, LEQEMBI IQLIK, or any of the ingredients.

Tell your healthcare provider if you notice any symptoms during or after a LEQEMBI infusion, including:

– swelling of the face, lips, mouth, or tongue

–itchy bumps on the skin, also known as hives

– difficulty breathing

Infusion-related reactions:

Infusion-related reactions can occur during or after completion with LEQEMBI injection into a vein (intravenously), which can be serious. Tell your healthcare provider right away if you notice any of these symptoms:

– fever

– flu-like symptoms (chills, body aches, feeling shaky, joint pain)

– nausea and/or vomiting

– dizziness or lightheadedness

– fast or slow heart rate, or feeling like your chest is pounding

– difficulty breathing or shortness of breath

– changes in blood pressure
If you have an infusion-related reaction, your healthcare provider may give you medicines before your next infusion to lower the chance of having a reaction

Injection-related reactions:

Injection-related reactions may occur with LEQEMBI injection under the skin (subcutaneous injection with LEQEMBI IQLIK). Tell your healthcare provider if you notice any of these symptoms during or after an injection:

– redness, swelling, heat, pain, itching, rash, bruising, and blood collection under the skin at the injection site

– headache, fatigue, or fever may also be observed after an injection

The most common side effects of LEQEMBI include infusion-related reactions, ARIA, and headaches.

These are not all the possible side effects of LEQEMBI. Call your doctor for more information and medical advice about side effects. You may report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

Before receiving LEQEMBI, tell your healthcare provider about:

All your medical conditions, including if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed. It is not known if LEQEMBI could harm your unborn or breastfeeding baby
All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines to reduce blood clots from forming (antithrombotic medicines, including aspirin)

LEQEMBI (lecanemab-irmb) is available as:

Intravenous infusion: 100 mg/mL
Subcutaneous injection: 200 mg/mL

Please see Medication Guide with Instructions for Use and full Prescribing Information, including Boxed WARNING, for LEQEMBI.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

This site is intended for residents of the United States only. The products discussed herein may have different product labeling in different countries. This Website contains information relating to various medical conditions and treatment. Such information is provided for educational purposes only and is not meant to be a substitute for the advice of a physician or other healthcare professionals. You should not use this information for diagnosing a health problem or disease. In order for you to make intelligent healthcare decisions, you should always consult with a physician or other healthcare provider for your, or your loved ones’, personal medical needs. Individual responses to treatment may vary.

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LEQE-US5205 March 2026
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LEQEMBI^® is a registered trademark of Eisai R&D Management Co., Ltd.
LEQEMBI Companion^™ and LEQEMBI IQLIK^™ are trademarks of Eisai R&D Management Co., Ltd.

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Eisai does not control the content or privacy policies of these third-party sites.

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