FREQUENTLY ASKED QUESTIONS

Common symptoms can include problems with memory, language, and thinking. However, there may be other symptoms beyond forgetfulness that close friends and family may notice. This is not a complete list of symptoms of Alzheimer's disease. Only a healthcare provider can diagnose Alzheimer's disease.

Learn more about MCI here.

Alzheimer's disease is a brain condition that gets worse over time. It may happen when a protein called amyloid continuously builds up in your brain, forming harmful amyloid brain plaque. Though there are different types of amyloid proteins, all of them can damage brain cells.

Learn more about the signs and symptoms of Alzheimer’s disease here.

Forgetfulness can be a normal part of aging, like misplacing items or forgetting to pay a bill. Alzheimer's disease causes more noticeable differences and impacts a person's daily life. People with Alzheimer's disease may have problems keeping track of the day or time of year, or struggle to have a conversation. This is not a complete list of symptoms of early Alzheimer's disease. Only a healthcare provider can diagnose early Alzheimer's disease.

Learn more about symptoms to look out for here.

Let your healthcare provider know about the symptoms you are experiencing. They may review your medical history or run a few tests or exams to determine what your symptoms are caused by.

Learn more about how you can have a productive conversation with your healthcare provider here.

There are 3 stages of Alzheimer’s disease when symptoms become more noticeable and impact daily life—early, middle, and late.

See the different stages of Alzheimer’s disease here.

Your healthcare provider will perform tests to confirm your specific diagnosis.

See the different stages of Alzheimer’s disease here.

Your healthcare provider may perform a cognitive or neurological exam, order lab tests, or have you take an MRI to evaluate your brain health. These can help figure out if your symptoms are due to early Alzheimer’s disease.

Learn more about these tests here.

LEQEMBI fights early Alzheimer’s disease by targeting different types of harmful amyloid proteins, and by removing existing amyloid brain plaque.

Watch this video to discover how LEQEMBI works throughout treatment.

Over time, it can build up and make it difficult to do things like think, remember, and problem-solve.

Watch this video to discover how LEQEMBI works throughout treatment.

LEQEMBI was proven to significantly slow the progression of Alzheimer’s disease in an 18-month study. Progression was measured using a Clinical Dementia Rating (CDR) scale by asking people how Alzheimer’s disease impacted different abilities.

Learn more about the LEQEMBI study here.

LEQEMBI may be right for you if you are in the early stage of Alzheimer’s disease, known as mild cognitive impairment (MCI) and mild dementia due to Alzheimer’s disease—when symptoms are still manageable without too much daily support.

Learn more about symptoms to look out for here.

Your healthcare provider will decide which tests are needed to check for amyloid brain plaque, such as a blood-based biomarker (BBM) test, amyloid positron emission tomography (PET) scan, or a cerebrospinal fluid (CSF) test.

Discover other tests you should know about here.

In an 18-month study of people with early Alzheimer’s disease, LEQEMBI was proven to significantly slow the progression of early Alzheimer's disease. Even though you cannot stop Alzheimer’s disease from getting worse, you can take steps to slow how fast it progresses.

Learn more about results with LEQEMBI here.

Some of the possible side effects of LEQEMBI include amyloid-related imaging abnormalities (ARIA), serious allergic reactions, infusion-related reactions, injection-related reactions, and/or headache.



Learn more about the potential side effects of LEQEMBI here.

Amyloid-related imaging abnormalities, or ARIA, is a potential serious side effect of treatments like LEQEMBI and can be fatal. It is most commonly seen as temporary swelling in areas of the brain that usually goes away over time.

Learn more about ARIA here.

Yes. Your healthcare provider will check for ARIA with MRI scans before you start LEQEMBI and about 1 week before your 3rd, 5th, 7th, and 14th infusions. Your exact MRI schedule will be determined by your healthcare provider and may include additional MRIs.

Some symptoms of ARIA include headache, confusion that gets worse, dizziness, vision changes, nausea, difficulty walking, seizures, difficulty speaking, and muscle weakness.

Get more information about ARIA here.

LEQEMBI is an intravenous (IV) infusion. This means a needle is placed in a vein in your arm to give the medicine.

Initially, infusions are given twice monthly (once every 2 weeks). It's a good idea to figure out transportation early so you can make a plan for each infusion appointment.

Infusions will be given at a healthcare provider’s office or an infusion center. Talk to your healthcare provider and insurance provider about where to get your infusions, or find a center here.

You can use the LEQEMBI infusion center locator to find a center near you.

Find an infusion center near youhere.

Each infusion takes about 1 hour.

If you miss an infusion of LEQEMBI, you should receive your next dose as soon as possible.

The LEQEMBI Companion™ app is designed to be a support tool to help you start and stay on track with your treatment. You can access a variety of features that you can use in every stage of your LEQEMBI treatment.

Learn all about the LEQEMBI Companion app here.

Your infusions keep LEQEMBI working in your body. Plus, these visits give your care team opportunities to check in on you. Let them know right away if anything comes up.

After 18 months of treatment, you may switch to maintenance infusions once monthly (once every 4 weeks) or at-home injections once weekly (once every 7 days). Alternatively, you may continue on your twice-monthly (once every 2 weeks) infusion schedule if you and your healthcare provider determine that’s the best plan for you.

After 18 months of treatment, talk to your healthcare provider about how you are doing on LEQEMBI and when might be the right time to reevaluate your treatment schedule. This could mean less frequent infusions or switching to at-home injections.

Each option keeps LEQEMBI working in your body and fighting Alzheimer’s disease. Everyone’s treatment experience may look a little different. Talk to your healthcare provider if you have any more questions about LEQEMBI.

Find questions to ask your healthcare provider here.

The right maintenance option for you can depend on factors like your experience with infusions so far, or your comfort with giving yourself (or with assistance from a care partner) injections at home with LEQEMBI IQLIK. Your healthcare provider will help you choose the best option to keep LEQEMBI working in your body.

Learn more about ongoing treatment options.

After 18 months of treatment, you may be able to switch to LEQEMBI IQLIK once-weekly (once every 7 days), at-home maintenance injections.

Your first at-home injection should be 2 weeks from your last infusion (after 18 months on LEQEMBI). Your healthcare provider can help answer any questions you may have about starting LEQEMBI IQLIK.

Yes. Ongoing treatment with either infusions or injections keeps LEQEMBI working in your body.

The LEQEMBI IQLIK autoinjector is designed to deliver a pre-measured dose of LEQEMBI just under the skin (a subcutaneous injection) without requiring a syringe.

Learn more about how to inject here.

You should use LEQEMBI IQLIK once weekly (once every 7 days). If you have any questions about your dosing schedule for at-home injections, reach out to your healthcare provider.

LEQEMBI IQLIK is given as an injection in the front of the thighs or stomach area (abdomen) by you or your care partner. Your care partner may also give you an injection in the back of the upper arms. Learn more about how to inject here.

Use this injection tracker to take note of your injections and where you’ve injected, so you can stay on top of your at-home injection schedule.

Do not inject into the 2-inch area around the belly button, or into moles, scars, bruises, tattoos, or into areas where the skin is red, hard, tender, or injured. Avoid injecting within 1 inch of the last injection site. Talk to your healthcare provider if you have any questions or concerns about where to inject. Learn more about where to inject here.

Do not replace the clear cap once it has been removed from the autoinjector. Doing so may damage the device, cause the medication to be released by mistake, or result in a needle injury. Do not put the clear cap back on after it has been removed from the autoinjector.

Yes, it is normal to see air bubbles inside your autoinjector. Be sure to inject at a 90º angle flat against the skin.

Learn more about how to inject here.

Be sure to inspect your autoinjector for particles or discoloration before injecting. The medication inside should be a clear and colorless to pale yellow solution, and free of visible particles. Do not use if the medicine looks cloudy, discolored, or contains particles.

If you believe your autoinjector is damaged, expired, has been dropped, or notice anything out of the ordinary, call 1-888-274-2378 or email esi_medinfo@eisai.com.

You may notice a small drop of blood on the area you injected in. This is normal, and you can press a cotton ball or gauze to the area, or put an adhesive bandage over it. Talk to your healthcare provider if you have any questions about side effects with LEQEMBI IQLIK.

Throughout the injection process, you may hear 2 clicks. The second click is a sign that the injection is complete. Make sure you don’t lift the autoinjector too early—keep holding the autoinjector in place for at least 5 more seconds after the injection is complete.

Learn more about how to inject with LEQEMBI IQLIK here.

LEQEMBI IQLIK autoinjectors contain the same medicine as the LEQEMBI infusions you've received.

A sharps disposal container is used to safely dispose of needles and other sharp objects. You may be able to request an FDA-cleared sharps container from your specialty pharmacy (they deliver your prescription for LEQEMBI in the mail to you).



If you do not have an FDA-cleared sharps container you may be able to use a household container that is made 
of heavy-duty plastic and can be closed with a tight-fitting puncture-resistant lid (such as a plastic laundry detergent bottle), without sharps being able to come out.



To learn more about safe sharps disposal and ways of getting a container, go to fda.gov/safesharpsdisposal.

If you have concerns about at-home injections, talk with your healthcare provider. They can help make sure you receive LEQEMBI in the way that works best for you.

Since LEQEMBI IQLIK needs to stay refrigerated, it will be delivered through a specialty pharmacy. The number of autoinjectors in each shipment will be determined by your healthcare provider and/or your specialty pharmacy.

If your shipment of LEQEMBI IQLIK doesn’t arrive by the expected date, reach out to your specialty pharmacy as soon as possible.

Your specialty pharmacy should contact you to coordinate your next shipment of LEQEMBI IQLIK. If your specialty pharmacy has not yet reached out and you only have 2 doses left, please contact them to avoid missing a dose.

If your shipment of LEQEMBI IQLIK doesn’t arrive by the expected date, reach out to your specialty pharmacy as soon as possible.

If the carton or the autoinjector is damaged, missing doses, or expired, call 1-888-274-2378 or email esi_medinfo@eisai.com.

If you miss a dose of LEQEMBI IQLIK, make sure to inject the missed dose as soon as possible up to 6 days after your missed dose. Continue (resume) your next injection on your regular dosing schedule. You can download the LEQEMBI Companion app to help you stay on track with your injection schedule, get reminders, and get personalized content. Download the app here.

As with any medicine, there’s a possibility that LEQEMBI could interact with something else you are taking. Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines to reduce blood clots from forming (antithrombic medicines, including aspirin). 

Yes, you can take LEQEMBI IQLIK with you on the go. Before you leave on a trip, always check the autoinjector to make sure it hasn’t expired. You should also consider getting a small sharps disposal container to bring with you.



Reach out to your specialty pharmacy in advance before your trip to let them know your schedule and make sure you have enough autoinjectors. They can help you arrange shipping to your destination, if necessary.



If you are flying, reach out to your airline to see if you can carry injection devices on the plane. At the airport, notify the TSA screener that you are carrying an autoinjector. It’s also a good idea to bring a doctor’s note with you if asked for one. 

LEQEMBI IQLIK should be stored in the refrigerator. Do not freeze. Keep it in the original carton to protect it from light until you are ready to inject. Ensure you keep your autoinjector and all medicines out of the reach of children.

LEQEMBI IQLIK is safe at room temperature (77 ºF/25 ºC) for up to 14 days in its original packaging, but should not go back into the refrigerator once it reaches room temperature.

Your healthcare provider can help answer any questions you may have about starting LEQEMBI IQLIK.

After enrolling in the LEQEMBI Companion™ program, you’ll have access to a Nurse Educator* who can provide injection support either in person or virtually. They cannot, however, provide medical advice. You can learn more about the LEQEMBI Companion program here.

If you're already enrolled and have questions, call 1-833-453-7362 (1-833-4-LEQEMBI).

*Nurse Educators are provided by Eisai and Biogen (manufacturers of LEQEMBI) and do not work under the direction of your healthcare provider.

Once you are prescribed LEQEMBI IQLIK, you will likely receive a practice autoinjector kit (without medication) from your specialty pharmacy or healthcare provider.

The kit may be delivered by mail or given in person. The kit is a helpful way to get familiar with injecting, but it is not needed to safely use LEQEMBI IQLIK.

If you do not receive your kit, contact the LEQEMBI Companion program by calling
1-833-453-7362 (1-833-4-LEQEMBI).

Doing things like coordinating appointments, helping keep track of injections, packing a treatment or infusion bag, and sharing your phone number with healthcare providers are all ways you can support your loved one as they adjust to LEQEMBI.

There are plenty of ways to help your loved one with their daily activities. Reminding them of their appointments, helping keep track of injections, setting up autopay for recurring bills, and prefilling a medication organizer are just a few.

Discover more ways you can help your loved one while they are on treatment here.

Joining local support groups and building a support network are great ways to help both yourself and your
loved one.

See more tips about how you can care for yourself here.

Start by asking your healthcare provider to enroll you in the LEQEMBI Companion program, which includes Eisai Patient Support (EPS). They can help identify potential financial support programs that you may be eligible for.

Learn more about the LEQEMBI Companion program and how to enroll here.

What you’ll pay for LEQEMBI depends on a number of different factors, like your prescription insurance, out-of-pocket costs, and your specific dose. Learn more about costs here.

People who are enrolled in the LEQEMBI Companion program may opt to sign up for Eisai Patient Support (EPS), which can help with understanding insurance coverage for LEQEMBI.

Learn more about how the LEQEMBI Companion program can help throughout treatment here.

The LEQEMBI Companion program is designed to help you start and stay on track with LEQEMBI. It offers resources and tools to support you throughout your treatment.

As a part of the LEQEMBI Companion program, Eisai Patient Support (EPS) offers information and resources to help with understanding insurance and financial assistance for LEQEMBI for eligible patients.

Learn more here.

The LEQEMBI Companion app is your digital partner designed to help support you at every step of your treatment. With the app, you have helpful information, as well as useful tools and tips you can return to throughout treatment. Learn more here.